Postdoctoral position in neurophysiology of social cognition and navigation, ELSC, Jerusalem

The Omer lab at Hebrew university of Jerusalem is seeking highly motivated post-doctoral fellows to participate in a research program aimed at elucidating the neural basis of social cognition and navigation in the primate brain. The lab is situated at the Edmond & Lily Safra center for brain sciences – a worldwide leading center in the field of neuroscience.

There are positions for each of the following two projects testing freely-moving marmoset monkeys:
(1) Neural basis of social cognition in the marmoset hippocampus.
(2) Spatial Navigation – neural basis of spatial navigation in freely behaving marmosets.
Candidates should have a strong scientific background in systems and/or computational neuroscience. Individuals with expertise in neurophysiological recordings in behaving animals (in primate or non-primate models), molecular technologies and/or computational analysis are particularly encouraged to apply.

The positions are funded by the Edmond and Lily Safra center for Brain Sciences, and are available immediately.

For more information or to apply for the position, please contact This email address is being protected from spambots. You need JavaScript enabled to view it..

Applicants should send a CV, brief statement of interest and a list of 2 references.

Elucidating the impact of aging on microglia activities and responses
by leveraging longitudinal in-vivo calcium imaging.
The Translational In-Vivo Sciences and Multiple Sclerosis & Neurorepair Research units at Biogen invite applications for a postdoctoral position in Neuroimmunology, applying systems neuroscience approaches to advance neuroimmunology research. Outstanding candidates working in all areas of Neurosciences and Neuroimmunology are invited to apply. The successful applicant will join a collaborative, multidisciplinary and dynamic group of high caliber neuroscientists and neuroimmunologists, whose common aim is to make breakthrough discoveries in our understanding of CNS diseases, and translate them into innovative therapeutics.
The project proposal will be discussed with the candidate(s), with the following primary goals: • Develop an innovative platform for in-vivo calcium imaging of microglia activity in behaving mice.
• Leverage this platform to advance our understanding of aging and its impact on microglia physiology in homeostatic and upon perturbation conditions.
• Translate findings into potential novel therapeutic applications targeting microglia functions relevant to brain physiology and physiopathology.
• Generate high-impact publications.
Biogen is equipped with the most cutting-edge in-vivo technologies (2-photon and 1-photon calcium imaging, electrophysiology and optogenetics), which offer unique opportunities to interrogate microglia functions in the native in vivo brain context. In addition, the MS & Neurorepair and Translational In vivo Sciences units constitute a uniquely motivating environment striving for technical and intellectual excellence in which the fellow will be fully integrated.
Applicants should have recently completed their Ph.D. studies in Neurosciences, or related biological sciences, with no more than 2 years of prior postdoctoral experience. The successful candidate will have a proven experience with in in-vivo recordings, preferably along with signal processing/image analysis and coding capabilities (e.g. MATLAB, Python). The candidate should be self-motivated with a strong interest in basic and translational research, and be passionate and driven to make impactful scientific discoveries which will impact our understanding of CNS diseases and ultimately treatments of patients suffering from these diseases.
Additionally, this position requires a track record of peer-reviewed publications, excellent communication skills, work ethics, and the ability to work independently as well as collaboratively within a highly matrixed environment.
Applications should include a cover letter, CV, list of publications, and references.
Please contact:
Dr. Yael Mandelblat-Cerf:
This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr. Michael Mingueneau
This email address is being protected from spambots. You need JavaScript enabled to view it.
Details about the Biogen Idec Postdoctoral Program can be found at:
https://www.biogen.com/en_us/postdoctoral-program.html

Description

We are seeking a highly motivated postdoctoral fellow to carry out a research project aiming to study the roles of Eph receptors in synaptic plasticity and memory formation. Toward that end, the successful applicant will utilize state-of-the-art molecular and cellular techniques and behavioral approaches including optogenetic (e.g. Alapin et al., Cell Reports, 2018).

Basic qualifications

- A recent PhD degree in neuroscience, molecular/cell biology or related fields.

- Experience in the following areas is desired: two-photon imaging/uncaging (e.g. imaging of dendritic spines, calcium imaging, glutamate uncaging), slice electrophysiology.

- High level of motivation and independence and the ability to think critically are expected.

An application package, including a motivation letter, curriculum vitae, list of publications and names of 2-3 referees, should be sent to This email address is being protected from spambots. You need JavaScript enabled to view it.

Prof. Raphael Lamprecht

Sagol Department of Neurobiology,

University of Haifa, Haifa, Israel

Websitehttps://rafilamprecht.wixsite.com/laboratorymemory

PhD candidate position is available at the Neuroimmunological laboratory at Rambam Healthcare Campus, lead by Dr. Ayal Rozenberg and managed by Dr. Dina Safina. Our main research focus is investigation of the mechanisms underlying multiple sclerosis (MS) pathophysiology in vitro, using patient-derived cells. We study different aspects of MS pathogenesis, which include: mitochondrial impairment; cross-talk between innate and adaptive immunity upon drug administration; cellular dynamics during pregnancy and postpartum. The research will be conducted in collaboration with Prof. Dorit Ben-Shahar and Prof. Nathi Karin at the Faculty of Medicine, Technion.

We are looking for a motivated, responsible, flexible and creative team member, who is ready to participate in method establishing and project shaping. Advantage will be given to candidates experienced in cell culture, flow cytometry, routine biochemical techniques, molecular biology and data analysis. Background in immunology, cell biology and neuroscience is welcome.
To apply, please send your CV to This email address is being protected from spambots. You need JavaScript enabled to view it.

                                                           

We are seeking highly motivated candidatesto fill several postdoctoral positions in the framework of the recently funded Horizon 2020 AND-PD research initiative.

The project focuses on the investigation of the causative mechanisms involved in co-morbidities linking Parkinson’s Disease with Anxiety and Depression.  

Parkinson’s Disease (PD) is clinically categorized as movement disorder. However, approximately 40% of the PD patients experience comorbid anxietyand depression, which are complex mental conditions recognized as the leading cause of disability worldwide, and one of the strongest predictors of quality of life in PD. Their relationship and pathophysiology are, however, poorly understood.

To investigate the neuronal substrates of anxiety and depression in PD, the international consortium builds on the experience of the partners working at the intersection between basic research and biomedical applications.  The successful candidates will perform a programme of pre-clinical research using established disease animal models, multiscale neuronal circuit investigation, behavioral, molecular and cellular omics analyses.

We are looking for candidates with one of the following

  • Expertise in neurophysiological and optogenetics ex-vivo and/or in-vivo combined with viral-based approaches to deconstruct and manipulate neuronal circuits, together with confocal microscopy, is a mandatory prerequisite. Previous experience with calcium imaging will be highly valued.

4 positions, respectively at

  • Expertise in the generation, molecular characterization and behavioural analysis of mouse models of Parkinson’s disease. The candidate should have extensive knowledge of stereotaxic surgery, and competence in the assessment of motor, and affective functions in naive and transgenic mice. Experience in immunofluorescence and confocal microscopy will be an important additional merit.

1 position: Laboratory of Molecular Neuropharmacology (Gilberto Fisone; https://ki.se/en/neuro/fisone-laboratory)

  • Expertise in neurophysiology, biochemistry and molecular biology applied to viral-based mice models of Parkinson’s disease aimed to explore key molecular determinants of neuronal dysfunction and cell death. Experience with mouse stereotaxic surgery, immunofluorescence and confocal microscopy is mandatory

1 position: Neurobiology of the Basal Ganglia group (Rosario MoratallaVillalba; http://www.cajal.csic.es/departamentos/moratalla-villalba/moratalla-villalba.html

  • Expertise in single-cell transcriptomics. The candidate should have extensive experience in RNA-seq analysis of gene expression. Bioinformatic skills are welcome. Experience in handling transgenic mice and brain tissues will add an important merit.

1 position: Non-coding RNAs and RNA-based therapeutics group (Stefano Gustincich; https://www.iit.it/research/lines/non-coding-rnas-and-rna-based-therapeutics)

The successful candidates will work in cutting-edge and highly collaborative research environments, and they will have the opportunity to train in the different laboratories of the research consortium to develop specific project tasks.

Candidates should hold a Ph.D. in either Physiology, Physics, Molecular Biology, Neuroscienceor related subjects, and have excellent written and verbal English communication skills. Applicants are expected to have a strong research track record and to be highly independent.

Salary will be commensurate to qualifications and experience and in line with international standards.

Applications, including detailed curriculum vitae, cover letter with indication of the targeted laboratories, and name and contacts of 2 referees, should be submitted in PDF format toThis email address is being protected from spambots. You need JavaScript enabled to view it.quoting “AND-PD Postdoctoral position” in the subject line.

Deadline 27th of January; short-list notification by the 1st of February; interview by TC on the 7th of February.

 

המעבדה לפסיכונוירואימונולוגיה באוניברסיטה העברית בירושלים היא מהמובילות בעולם במחקר של הקשרים בין מערכת החיסון, המח ותהליכים ריגשיים וקוגניטיביים. המעבדה מתמקדת בחקר המעורבות של תהליכים דלקתיים ושל פעילות תאי מיקרוגליה במח במחלות נוירו-פסיכיאטריות, כולל דיכאון ומחלות נוירודגנרטיביות (ראו אתר המעבדה https://scholars.huji.ac.il/razyirmiya/home).

למעבדה דרוש/ה חוקר/ת בכיר/ה שישתלב/תשתלב בהובלת פרויקט מחקר ופיתוח של תרופות חדשניות למחלות נוירו-פסיכיאטריות

דרישות התפקיד:

תואר דוקטור במדעי המח, נוירואימונולוגיה, אימונולוגיה או תחום קרוב

ניסיון מחקרי משמעותי ויכולת להוביל מחקר עצמאי ויצירתי

ניסיון במדידת ביטוי גנים  (RT-PCR, RNA-Seq)

ניסיון באיפיון תאים של מערכת החיסון

ניסיון באימונוהיסטוכימיה

ניסיון מחקרי שקשור לתהליכים דלקתיים, כולל מדידת ריכוזי ציטוקינים ומרקרים דלקתיים אחרים, עבודה עם תרביות תאים, ומודלים של תהליכים דלקתיים בחיות ניסוי

ניסיון בעבודה עם דגימות דם בבני אדם מהווה יתרון

יכולת וניסיון בהובלת צוות של עוזרי מעבדה/טכנאים במעבדה

ידע וניסיון ספציפי בתחום הנוירואימונולוגיה, כולל עבודה עם מודלים של מחלות נוירולוגיות בחיות ניסוי, ניסיון בהפרדה של תאים מרקמות מח ואיפיון של תאים אלה בשיטות שונות, ניסיון בהפקת primary cultures של תאים במח, וכד', מהווים יתרון ויוכלו לתרום להצלחת הפרויקט.

מועמדים/ות מתאימים/ות יקבלו משרה אקדמית במסלול חוקרים באוניברסיטה העברית (https://hr.huji.ac.il/hokrim), בדרגה ההולמת את מעמדם האקדמי.

לפרטים נוספים, נא לפנות לפרופ' רז ירמיה, המעבדה לפסיכונוירואימונולוגיה, המחלקה לפסיכולוגיה באוניברסיטה העברית, במייל This email address is being protected from spambots. You need JavaScript enabled to view it., בצרוף קורות חיים.

Analysis of stimulus-induced brain dynamics during naturalistic paradigms

using high-resolution 7-Tesla fMRI

Faculty: Faculty of Biology

Department: Department of Neurobiology, Weizmann Institute of science

Naturalistic stimuli offer promising avenues for investigating brain function across the rich, realistic spectrum of human experiences. Functional magnetic resonance imaging (fMRI) studies of brain activity recorded during naturalistic paradigms have provided new information about dynamic neural processing in ecologically valid contexts, but the complex, uncontrolled nature of such stimuli -- and the resulting, multifaceted fMRI responses that unfold -- present challenges with respect to data analysis and interpretation.

The post-doctorate project will involve first experimental phase: conducting fMRI experiments using a newly established 7T MRI scanner during naturalistic stimulation (auditory-narratives or movies), together with recording physiological measures: pupil size, heart rate, and respiration. (ii) Developing new signal processing methods to disentangle cognitive processing from autonomic responses, and physiological “noise”, targeting memory encoding and retrieval processes.

The position is for one year starting at December 2019. Following a positive evaluation, the appointment could be extended up to 2 years.

Requirements:

Strong computational, analytical and programming skills.
Experience with fMRI and experimental work – an advantage.
Computational/engineering/physics background and programming experience.
Ability of teamwork and initiative.
Knowledge of professional English at a high level.


Details of Contact Person for Position:

The work will take place at the Lab of Dr. Ritta Schmidt (Weizmann institute of science) and will be supervised directly by Dr. Erez Simony from Holon Institute of technology (HIT).
Prof. Rafi Malach will act as an advisor to this project.

How to apply:

Interested candidates with proven academic record are requested to send their CV and contact details of 3 referees to Dr. Erez Simony (This email address is being protected from spambots. You need JavaScript enabled to view it.)

The Ben-Shaul lab at the Hebrew University Faculty of Medicine is seeking PhD students and postdoctoral fellows to join our research on chemosensory processing of social signals.
Our lab is interested in basic aspects of sensory coding as well as more ethological questions about the interplay between learned and innate behaviors.

Work in the lab involves one or more of the following approaches: electrophysiology, behavioral testing (using optogenetics), activity based gene trapping, and data analyses.
For more information, visit our website (https://yoramben-shaul.ekmd.huji.ac.il/).
Applicants should email Yoram Ben-Shaul  (This email address is being protected from spambots. You need JavaScript enabled to view it.), describing their previous experience in the field of neuroscience and their research interests.
Substantial fellowships are guaranteed to suitable and dedicated candidates.