Elucidating the impact of aging on microglia activities and responses
by leveraging longitudinal in-vivo calcium imaging.
The Translational In-Vivo Sciences and Multiple Sclerosis & Neurorepair Research units at Biogen invite applications for a postdoctoral position in Neuroimmunology, applying systems neuroscience approaches to advance neuroimmunology research. Outstanding candidates working in all areas of Neurosciences and Neuroimmunology are invited to apply. The successful applicant will join a collaborative, multidisciplinary and dynamic group of high caliber neuroscientists and neuroimmunologists, whose common aim is to make breakthrough discoveries in our understanding of CNS diseases, and translate them into innovative therapeutics.
The project proposal will be discussed with the candidate(s), with the following primary goals: • Develop an innovative platform for in-vivo calcium imaging of microglia activity in behaving mice.
• Leverage this platform to advance our understanding of aging and its impact on microglia physiology in homeostatic and upon perturbation conditions.
• Translate findings into potential novel therapeutic applications targeting microglia functions relevant to brain physiology and physiopathology.
• Generate high-impact publications.
Biogen is equipped with the most cutting-edge in-vivo technologies (2-photon and 1-photon calcium imaging, electrophysiology and optogenetics), which offer unique opportunities to interrogate microglia functions in the native in vivo brain context. In addition, the MS & Neurorepair and Translational In vivo Sciences units constitute a uniquely motivating environment striving for technical and intellectual excellence in which the fellow will be fully integrated.
Applicants should have recently completed their Ph.D. studies in Neurosciences, or related biological sciences, with no more than 2 years of prior postdoctoral experience. The successful candidate will have a proven experience with in in-vivo recordings, preferably along with signal processing/image analysis and coding capabilities (e.g. MATLAB, Python). The candidate should be self-motivated with a strong interest in basic and translational research, and be passionate and driven to make impactful scientific discoveries which will impact our understanding of CNS diseases and ultimately treatments of patients suffering from these diseases.
Additionally, this position requires a track record of peer-reviewed publications, excellent communication skills, work ethics, and the ability to work independently as well as collaboratively within a highly matrixed environment.
Applications should include a cover letter, CV, list of publications, and references.
Please contact:
Dr. Yael Mandelblat-Cerf:
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Dr. Michael Mingueneau
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Details about the Biogen Idec Postdoctoral Program can be found at:
https://www.biogen.com/en_us/postdoctoral-program.html